diff --git a/packages/@react-aria/focus/src/FocusScope.tsx b/packages/@react-aria/focus/src/FocusScope.tsx
index 0a0dc1310f4..d995abc7cc1 100644
--- a/packages/@react-aria/focus/src/FocusScope.tsx
+++ b/packages/@react-aria/focus/src/FocusScope.tsx
@@ -331,6 +331,7 @@ function isTabbableRadio(element: HTMLInputElement): boolean {
 
 function useFocusContainment(scopeRef: RefObject<Element[] | null>, contain?: boolean) {
   let focusedNode = useRef<FocusableElement>(undefined);
+  let lastPointerDownTarget = useRef<Element | null>(null);
 
   let raf = useRef<ReturnType<typeof requestAnimationFrame>>(undefined);
   useLayoutEffect(() => {
@@ -395,6 +396,10 @@ function useFocusContainment(scopeRef: RefObject<Element[] | null>, contain?: bo
       }
     };
 
+    let onPointerDown: EventListener = (e) => {
+      lastPointerDownTarget.current = getEventTarget(e) as Element;
+    };
+
     let onBlur: EventListener = (e) => {
       // Firefox doesn't shift focus back to the Dialog properly without this
       if (raf.current) {
@@ -407,27 +412,57 @@ function useFocusContainment(scopeRef: RefObject<Element[] | null>, contain?: bo
         let modality = getInteractionModality();
         let shouldSkipFocusRestore = (modality === 'virtual' || modality === null) && isAndroid() && isChrome();
 
-        // Use document.activeElement instead of e.relatedTarget so we can tell if user clicked into iframe
         let activeElement = getActiveElement(ownerDocument);
-        if (!shouldSkipFocusRestore && activeElement && shouldContainFocus(scopeRef) && !isElementInChildScope(activeElement, scopeRef)) {
-          activeScope = scopeRef;
-          let target = getEventTarget(e) as FocusableElement;
-          if (target && target.isConnected) {
-            focusedNode.current = target;
-            focusedNode.current?.focus();
-          } else if (activeScope.current) {
-            focusFirstInScope(activeScope.current);
+        let shouldContain = !shouldSkipFocusRestore && shouldContainFocus(scopeRef) && (!activeElement || !isElementInChildScope(activeElement, scopeRef));
+        if (!shouldContain) {
+          lastPointerDownTarget.current = null;
+          return;
+        }
+
+        activeScope = scopeRef;
+        // Safari moves focus to body when clicking a focusable element (e.g. button); relatedTarget is null.
+        // Use the pointerdown target so we focus what the user actually clicked instead of the element that lost focus.
+        let pointerTarget = lastPointerDownTarget.current;
+        let safariFocusTarget: FocusableElement | null = null;
+        if (activeElement === ownerDocument.body && pointerTarget?.isConnected && isElementInChildScope(pointerTarget, scopeRef)) {
+          safariFocusTarget = isFocusable(pointerTarget as FocusableElement) ? (pointerTarget as FocusableElement) : null;
+          if (!safariFocusTarget && pointerTarget instanceof Element) {
+            let el: Element | null = pointerTarget;
+            while (el && isElementInChildScope(el, scopeRef)) {
+              if (isFocusable(el as FocusableElement)) {
+                safariFocusTarget = el as FocusableElement;
+                break;
+              }
+              el = el.parentElement;
+            }
           }
         }
+        lastPointerDownTarget.current = null;
+
+        if (safariFocusTarget?.isConnected && isElementInChildScope(safariFocusTarget, scopeRef)) {
+          focusedNode.current = safariFocusTarget;
+          focusElement(safariFocusTarget);
+          return;
+        }
+
+        let target = getEventTarget(e) as FocusableElement;
+        if (target && target.isConnected) {
+          focusedNode.current = target;
+          focusedNode.current?.focus();
+        } else if (activeScope.current) {
+          focusFirstInScope(activeScope.current);
+        }
       });
     };
 
     ownerDocument.addEventListener('keydown', onKeyDown, false);
+    ownerDocument.addEventListener('pointerdown', onPointerDown, true);
     ownerDocument.addEventListener('focusin', onFocus, false);
     scope?.forEach(element => element.addEventListener('focusin', onFocus, false));
     scope?.forEach(element => element.addEventListener('focusout', onBlur, false));
     return () => {
       ownerDocument.removeEventListener('keydown', onKeyDown, false);
+      ownerDocument.removeEventListener('pointerdown', onPointerDown, true);
       ownerDocument.removeEventListener('focusin', onFocus, false);
       scope?.forEach(element => element.removeEventListener('focusin', onFocus, false));
       scope?.forEach(element => element.removeEventListener('focusout', onBlur, false));
diff --git a/packages/@react-spectrum/s2/stories/Button.stories.tsx b/packages/@react-spectrum/s2/stories/Button.stories.tsx
index a4108053a4f..89cfb3c9fe1 100644
--- a/packages/@react-spectrum/s2/stories/Button.stories.tsx
+++ b/packages/@react-spectrum/s2/stories/Button.stories.tsx
@@ -13,10 +13,12 @@
 import {action} from 'storybook/actions';
 import {Button, Text} from '../src';
 import {categorizeArgTypes, getActionArgs, StaticColorDecorator} from './utils';
+import {FocusScope} from '@react-aria/focus';
 import type {Meta, StoryObj} from '@storybook/react';
 import NewIcon from '../s2wf-icons/S2_Icon_New_20_N.svg';
 import {style} from '../style/spectrum-theme' with { type: 'macro' };
 import {useEffect, useRef, useState} from 'react';
+import './buttonstyles.css';
 
 const events = ['onPress', 'onPressChange', 'onPressEnd', 'onPressStart', 'onPressUp'];
 
@@ -109,3 +111,32 @@ function PendingButtonExample(props) {
       onPress={handlePress} />
   );
 }
+
+export function App() {
+  return (
+    <div className="App">
+      <h1>Hello, My React Aria Problem</h1>
+      <h2>
+        Click the input at the top of the scrollable content, then try clicking
+        the button at the bottom.
+      </h2>
+
+      <FocusScope restoreFocus autoFocus contain>
+        <div className="ScollContainer">
+          <input className="Input" placeholder="INPUT" />
+
+          <span className="StickyElement">Scroll to input ...</span>
+          <span className="Spacer" />
+
+          <button
+            className="Button"
+            onClick={() => {
+              console.log('WIN!');
+            }}>
+            BUTTON
+          </button>
+        </div>
+      </FocusScope>
+    </div>
+  );
+}
diff --git a/packages/@react-spectrum/s2/stories/buttonstyles.css b/packages/@react-spectrum/s2/stories/buttonstyles.css
new file mode 100644
index 00000000000..0c86f65d2b8
--- /dev/null
+++ b/packages/@react-spectrum/s2/stories/buttonstyles.css
@@ -0,0 +1,64 @@
+.App {
+  font-family: sans-serif;
+  text-align: center;
+}
+
+* {
+  box-sizing: border-box;
+}
+
+.ScollContainer {
+  position: relative;
+  display: flex;
+  flex-direction: column;
+  width: 100%;
+  height: 200px;
+  overflow: auto;
+  padding: 24px;
+  border: 1px solid black;
+  background-color: #eee;
+}
+
+.Button {
+  display: flex;
+  justify-content: center;
+  align-items: center;
+  width: 100%;
+  height: 64px;
+  flex-shrink: 0;
+  font-size: 24px;
+  font-weight: 700;
+  border: 1px solid royalblue;
+  background: royalblue;
+}
+
+.StickyElement {
+  position: sticky;
+  top: 0;
+  display: flex;
+  justify-content: center;
+  align-items: center;
+  width: 100%;
+  height: 64px;
+  flex-shrink: 0;
+  font-size: 24px;
+  font-weight: 700;
+}
+
+.Spacer {
+  display: flex;
+  flex-shrink: 0;
+  width: 100%;
+  height: 1000px;
+}
+
+.Input {
+  display: block;
+  width: 100%;
+  height: 64px;
+  padding: 0 24px;
+  flex-shrink: 0;
+  font-size: 24px;
+  font-weight: 700;
+  border: 1px solid royalblue;
+}