diff --git a/flow-typed/environment/node.js b/flow-typed/environment/node.js
index 6f9d2a0cb802..c2f5626e3be4 100644
--- a/flow-typed/environment/node.js
+++ b/flow-typed/environment/node.js
@@ -618,7 +618,7 @@ declare class crypto$Hash extends stream$Duplex {
     data: string | Buffer,
     input_encoding?: 'utf8' | 'ascii' | 'latin1' | 'binary',
   ): crypto$Hash;
-  copy(options?: mixed): crypto$Hash;
+  copy(options?: unknown): crypto$Hash;
 }
 
 declare class crypto$Hmac extends stream$Duplex {
@@ -703,7 +703,7 @@ declare class crypto$KeyObject {
       format: 'der',
     }>,
   ): Buffer;
-  export(options: Readonly<{format: 'jwk'}>): mixed;
+  export(options: Readonly<{format: 'jwk'}>): unknown;
   equals(otherKeyObject: crypto$KeyObject): boolean;
 }
 
@@ -739,7 +739,7 @@ declare class crypto$X509Certificate {
   checkIssued(otherCert: crypto$X509Certificate): boolean;
   checkPrivateKey(privateKey: crypto$KeyObject): boolean;
   toJSON(): string;
-  toLegacyObject(): mixed;
+  toLegacyObject(): unknown;
   toString(): string;
   verify(publicKey: crypto$KeyObject): boolean;
 }
@@ -930,10 +930,10 @@ declare module 'crypto' {
     encoding: buffer$Encoding,
   ): crypto$KeyObject;
   declare function createPublicKey(
-    key: string | Buffer | crypto$KeyObject | mixed,
+    key: string | Buffer | crypto$KeyObject | unknown,
   ): crypto$KeyObject;
   declare function createPrivateKey(
-    key: string | Buffer | mixed,
+    key: string | Buffer | unknown,
   ): crypto$KeyObject;
   declare function generateKeyPair(
     type:
@@ -945,7 +945,7 @@ declare module 'crypto' {
       | 'ed448'
       | 'x25519'
       | 'x448',
-    options: mixed,
+    options: unknown,
     callback: (
       err: ?Error,
       publicKey: crypto$KeyObject,
@@ -962,7 +962,7 @@ declare module 'crypto' {
       | 'ed448'
       | 'x25519'
       | 'x448',
-    options: mixed,
+    options: unknown,
   ): {publicKey: crypto$KeyObject, privateKey: crypto$KeyObject, ...};
   declare function generateKey(
     type: 'hmac' | 'aes',
@@ -2011,8 +2011,8 @@ declare module 'fs' {
       | Buffer
       | Uint8Array
       | DataView
-      | AsyncIterable<mixed>
-      | Iterable<mixed>
+      | AsyncIterable<unknown>
+      | Iterable<unknown>
       | stream$Readable,
     options: WriteOptions | string,
   ) => Promise<void>;
@@ -2908,17 +2908,19 @@ declare module 'perf_hooks' {
     +entryType: EntryType;
     +name: string;
     +startTime: number;
-    +detail?: mixed;
-    toJSON(): mixed;
+    +detail?: unknown;
+    toJSON(): unknown;
   }
 
-  declare export class PerformanceMark<T = mixed> extends PerformanceEntry {
+  declare export class PerformanceMark<T = unknown> extends PerformanceEntry {
     +entryType: 'mark';
     +duration: 0;
     +detail?: T;
   }
 
-  declare export class PerformanceMeasure<T = mixed> extends PerformanceEntry {
+  declare export class PerformanceMeasure<T = unknown>
+    extends PerformanceEntry
+  {
     +entryType: 'measure';
     +detail?: T;
   }
@@ -2987,12 +2989,12 @@ declare module 'perf_hooks' {
     +active: number,
   };
 
-  declare export type PerformanceMarkOptions<T = mixed> = Readonly<{
+  declare export type PerformanceMarkOptions<T = unknown> = Readonly<{
     detail?: T,
     startTime?: number,
   }>;
 
-  declare export type PerformanceMeasureOptions<T = mixed> = Readonly<{
+  declare export type PerformanceMeasureOptions<T = unknown> = Readonly<{
     detail?: T,
     duration?: number,
     end?: number | string,
@@ -3023,11 +3025,11 @@ declare module 'perf_hooks' {
     now(): number;
     setResourceTimingBufferSize(maxSize: number): void;
     +timeOrigin: number;
-    timerify<TArgs: Iterable<mixed>, TReturn>(
+    timerify<TArgs: Iterable<unknown>, TReturn>(
       fn: (...TArgs) => TReturn,
       options?: Readonly<{histogram?: RecordableHistogram}>,
     ): (...TArgs) => TReturn;
-    toJSON(): mixed;
+    toJSON(): unknown;
   }
 
   declare export var performance: Performance;
@@ -3720,20 +3722,20 @@ declare module 'timers' {
     // [key: $SymbolDispose]: () => void;
   }
 
-  declare export function setTimeout<TArgs: Iterable<mixed>>(
-    callback: (...args: TArgs) => mixed,
+  declare export function setTimeout<TArgs: Iterable<unknown>>(
+    callback: (...args: TArgs) => unknown,
     delay?: number,
     ...args: TArgs
   ): Timeout;
 
-  declare export function setInterval<TArgs: Iterable<mixed>>(
-    callback: (...args: TArgs) => mixed,
+  declare export function setInterval<TArgs: Iterable<unknown>>(
+    callback: (...args: TArgs) => unknown,
     delay?: number,
     ...args: TArgs
   ): Timeout;
 
-  declare export function setImmediate<TArgs: Iterable<mixed>>(
-    callback: (...args: TArgs) => mixed,
+  declare export function setImmediate<TArgs: Iterable<unknown>>(
+    callback: (...args: TArgs) => unknown,
     ...args: TArgs
   ): Immediate;
 
diff --git a/flow-typed/npm/babel-traverse_v7.x.x.js b/flow-typed/npm/babel-traverse_v7.x.x.js
index 0726aef6da8d..bbebfb8332bd 100644
--- a/flow-typed/npm/babel-traverse_v7.x.x.js
+++ b/flow-typed/npm/babel-traverse_v7.x.x.js
@@ -556,24 +556,24 @@ declare module '@babel/traverse' {
      * Check whether we have the input `key`. If the `key` references an array then we check
      * if the array has any items, otherwise we just check if it's falsy.
      */
-    has(key: $Keys<TNode>): boolean;
+    has(key: keyof TNode): boolean;
 
     isStatic(): boolean;
 
     /**
      * Alias of `has`.
      */
-    is(key: $Keys<TNode>): boolean;
+    is(key: keyof TNode): boolean;
 
     /**
      * Opposite of `has`.
      */
-    isnt(key: $Keys<TNode>): boolean;
+    isnt(key: keyof TNode): boolean;
 
     /**
      * Check whether the path node `key` strict equals `value`.
      */
-    equals(key: $Keys<TNode>, value: any): boolean;
+    equals(key: keyof TNode, value: any): boolean;
 
     /**
      * Check the type against our stored internal type of the node. This is handy when a node has
@@ -724,7 +724,7 @@ declare module '@babel/traverse' {
 
     getAllPrevSiblings(): Array<NodePath<>>;
 
-    get<TKey: $Keys<TNode>>(
+    get<TKey: keyof TNode>(
       key: TKey,
       context?: boolean | TraversalContext,
     ): TNode[TKey] extends BabelNode ? NodePath<> : Array<NodePath<>>;
diff --git a/flow-typed/npm/rxjs_v6.x.x.js b/flow-typed/npm/rxjs_v6.x.x.js
index 6bc8eb1d3f29..a8c085b8a548 100644
--- a/flow-typed/npm/rxjs_v6.x.x.js
+++ b/flow-typed/npm/rxjs_v6.x.x.js
@@ -2193,10 +2193,10 @@ declare module 'rxjs/operators' {
   ): rxjs$MonoTypeOperatorFunction<T>;
 
   declare export function distinctUntilKeyChanged<T>(
-    key: $Keys<T>,
+    key: keyof T,
   ): rxjs$MonoTypeOperatorFunction<T>;
 
-  declare export function distinctUntilKeyChanged<T, K: $Keys<T>>(
+  declare export function distinctUntilKeyChanged<T, K: keyof T>(
     key: K,
     compare: (x: unknown, y: unknown) => boolean,
   ): rxjs$MonoTypeOperatorFunction<T>;
diff --git a/packages/dev-middleware/src/inspector-proxy/Device.js b/packages/dev-middleware/src/inspector-proxy/Device.js
index ad29acf8668f..6bdab2cd891e 100644
--- a/packages/dev-middleware/src/inspector-proxy/Device.js
+++ b/packages/dev-middleware/src/inspector-proxy/Device.js
@@ -480,7 +480,7 @@ export default class Device {
   /**
    * Returns `true` if a page supports the given target capability flag.
    */
-  #pageHasCapability(page: Page, flag: $Keys<TargetCapabilityFlags>): boolean {
+  #pageHasCapability(page: Page, flag: keyof TargetCapabilityFlags): boolean {
     return page.capabilities[flag] === true;
   }
 
diff --git a/packages/dev-middleware/src/inspector-proxy/cdp-types/messages.js b/packages/dev-middleware/src/inspector-proxy/cdp-types/messages.js
index b06c447b3b37..e2c0e2d3fa6d 100644
--- a/packages/dev-middleware/src/inspector-proxy/cdp-types/messages.js
+++ b/packages/dev-middleware/src/inspector-proxy/cdp-types/messages.js
@@ -12,18 +12,18 @@ import type {JSONSerializable} from '../types';
 import type {Commands, Events} from './protocol';
 
 // Note: A CDP event is a JSON-RPC notification with no `id` member.
-export type CDPEvent<TEvent: $Keys<Events> = 'unknown'> = {
+export type CDPEvent<TEvent: keyof Events = 'unknown'> = {
   method: TEvent,
   params: Events[TEvent],
 };
 
-export type CDPRequest<TCommand: $Keys<Commands> = 'unknown'> = {
+export type CDPRequest<TCommand: keyof Commands = 'unknown'> = {
   method: TCommand,
   params: Commands[TCommand]['paramsType'],
   id: number,
 };
 
-export type CDPResponse<TCommand: $Keys<Commands> = 'unknown'> =
+export type CDPResponse<TCommand: keyof Commands = 'unknown'> =
   | {
       result: Commands[TCommand]['resultType'],
       id: number,
diff --git a/packages/react-native/Libraries/Animated/createAnimatedComponent.js b/packages/react-native/Libraries/Animated/createAnimatedComponent.js
index d8fcb31bd636..4668a7ece376 100644
--- a/packages/react-native/Libraries/Animated/createAnimatedComponent.js
+++ b/packages/react-native/Libraries/Animated/createAnimatedComponent.js
@@ -65,9 +65,9 @@ type PassThroughProps = Readonly<{
   passthroughAnimatedPropExplicitValues?: ViewProps | null,
 }>;
 
-type LooseOmit<O: interface {}, K: $Keys<$FlowFixMe>> = Pick<
+type LooseOmit<O: interface {}, K: keyof $FlowFixMe> = Pick<
   O,
-  Exclude<$Keys<O>, K>,
+  Exclude<keyof O, K>,
 >;
 
 export type AnimatedProps<Props: {...}> = LooseOmit<
diff --git a/packages/react-native/Libraries/AppState/AppState.js b/packages/react-native/Libraries/AppState/AppState.js
index 7c018733ff7e..b1456ec048e2 100644
--- a/packages/react-native/Libraries/AppState/AppState.js
+++ b/packages/react-native/Libraries/AppState/AppState.js
@@ -42,7 +42,7 @@ type AppStateEventDefinitions = {
   focus: [],
 };
 
-export type AppStateEvent = $Keys<AppStateEventDefinitions>;
+export type AppStateEvent = keyof AppStateEventDefinitions;
 
 type NativeAppStateEventDefinitions = {
   appStateDidChange: [{app_state: AppStateStatus}],
diff --git a/packages/react-native/Libraries/Components/AccessibilityInfo/AccessibilityInfo.js b/packages/react-native/Libraries/Components/AccessibilityInfo/AccessibilityInfo.js
index 9e1d236c9288..223f6149ddbc 100644
--- a/packages/react-native/Libraries/Components/AccessibilityInfo/AccessibilityInfo.js
+++ b/packages/react-native/Libraries/Components/AccessibilityInfo/AccessibilityInfo.js
@@ -49,30 +49,28 @@ type AccessibilityEventTypes =
   | 'windowStateChange';
 
 // Mapping of public event names to platform-specific event names.
-const EventNames: Map<
-  $Keys<AccessibilityEventDefinitions>,
-  string,
-> = Platform.OS === 'android'
-  ? new Map([
-      ['change', 'touchExplorationDidChange'],
-      ['reduceMotionChanged', 'reduceMotionDidChange'],
-      ['highTextContrastChanged', 'highTextContrastDidChange'],
-      ['screenReaderChanged', 'touchExplorationDidChange'],
-      ['accessibilityServiceChanged', 'accessibilityServiceDidChange'],
-      ['invertColorsChanged', 'invertColorDidChange'],
-      ['grayscaleChanged', 'grayscaleModeDidChange'],
-    ])
-  : new Map([
-      ['announcementFinished', 'announcementFinished'],
-      ['boldTextChanged', 'boldTextChanged'],
-      ['change', 'screenReaderChanged'],
-      ['grayscaleChanged', 'grayscaleChanged'],
-      ['invertColorsChanged', 'invertColorsChanged'],
-      ['reduceMotionChanged', 'reduceMotionChanged'],
-      ['reduceTransparencyChanged', 'reduceTransparencyChanged'],
-      ['screenReaderChanged', 'screenReaderChanged'],
-      ['darkerSystemColorsChanged', 'darkerSystemColorsChanged'],
-    ]);
+const EventNames: Map<keyof AccessibilityEventDefinitions, string> =
+  Platform.OS === 'android'
+    ? new Map([
+        ['change', 'touchExplorationDidChange'],
+        ['reduceMotionChanged', 'reduceMotionDidChange'],
+        ['highTextContrastChanged', 'highTextContrastDidChange'],
+        ['screenReaderChanged', 'touchExplorationDidChange'],
+        ['accessibilityServiceChanged', 'accessibilityServiceDidChange'],
+        ['invertColorsChanged', 'invertColorDidChange'],
+        ['grayscaleChanged', 'grayscaleModeDidChange'],
+      ])
+    : new Map([
+        ['announcementFinished', 'announcementFinished'],
+        ['boldTextChanged', 'boldTextChanged'],
+        ['change', 'screenReaderChanged'],
+        ['grayscaleChanged', 'grayscaleChanged'],
+        ['invertColorsChanged', 'invertColorsChanged'],
+        ['reduceMotionChanged', 'reduceMotionChanged'],
+        ['reduceTransparencyChanged', 'reduceTransparencyChanged'],
+        ['screenReaderChanged', 'screenReaderChanged'],
+        ['darkerSystemColorsChanged', 'darkerSystemColorsChanged'],
+      ]);
 
 /**
  * Sometimes it's useful to know whether or not the device has a screen reader
@@ -426,7 +424,7 @@ const AccessibilityInfo = {
    *
    * See https://reactnative.dev/docs/accessibilityinfo#addeventlistener
    */
-  addEventListener<K: $Keys<AccessibilityEventDefinitions>>(
+  addEventListener<K: keyof AccessibilityEventDefinitions>(
     eventName: K,
     // $FlowFixMe[incompatible-type] - Flow bug with unions and generics (T128099423)
     handler: (...AccessibilityEventDefinitions[K]) => void,
diff --git a/packages/react-native/Libraries/Components/Keyboard/Keyboard.js b/packages/react-native/Libraries/Components/Keyboard/Keyboard.js
index a17be856521c..b5e1e3a37b1f 100644
--- a/packages/react-native/Libraries/Components/Keyboard/Keyboard.js
+++ b/packages/react-native/Libraries/Components/Keyboard/Keyboard.js
@@ -16,7 +16,7 @@ import dismissKeyboard from '../../Utilities/dismissKeyboard';
 import Platform from '../../Utilities/Platform';
 import NativeKeyboardObserver from './NativeKeyboardObserver';
 
-export type KeyboardEventName = $Keys<KeyboardEventDefinitions>;
+export type KeyboardEventName = keyof KeyboardEventDefinitions;
 
 export type KeyboardEventEasing =
   | 'easeIn'
@@ -146,7 +146,7 @@ class KeyboardImpl {
    *
    * @param {function} callback function to be called when the event fires.
    */
-  addListener<K: $Keys<KeyboardEventDefinitions>>(
+  addListener<K: keyof KeyboardEventDefinitions>(
     eventType: K,
     listener: (...KeyboardEventDefinitions[K]) => unknown,
     context?: unknown,
@@ -159,7 +159,7 @@ class KeyboardImpl {
    *
    * @param {string} eventType The native event string listeners are watching which will be removed.
    */
-  removeAllListeners<K: $Keys<KeyboardEventDefinitions>>(eventType: ?K): void {
+  removeAllListeners<K: keyof KeyboardEventDefinitions>(eventType: ?K): void {
     this._emitter.removeAllListeners(eventType);
   }
 
diff --git a/packages/react-native/Libraries/Components/ProgressBarAndroid/ProgressBarAndroid.js b/packages/react-native/Libraries/Components/ProgressBarAndroid/ProgressBarAndroid.js
index 7d51999f5e6c..447327cb6695 100644
--- a/packages/react-native/Libraries/Components/ProgressBarAndroid/ProgressBarAndroid.js
+++ b/packages/react-native/Libraries/Components/ProgressBarAndroid/ProgressBarAndroid.js
@@ -21,7 +21,7 @@ export type {ProgressBarAndroidProps};
 // of ProgressBarAndroidProps. TS's Omit does not distribute over unions, so
 // we define our own version which does. This does not affect Flow.
 // $FlowExpectedError[unclear-type]
-type Omit<T, K> = T extends any ? Pick<T, Exclude<$Keys<T>, K>> : T;
+type Omit<T, K> = T extends any ? Pick<T, Exclude<keyof T, K>> : T;
 
 /**
  * ProgressBarAndroid has been extracted from react-native core and will be removed in a future release.
diff --git a/packages/react-native/Libraries/Components/StatusBar/StatusBar.js b/packages/react-native/Libraries/Components/StatusBar/StatusBar.js
index 396ed4047e28..5df3131bdcf0 100644
--- a/packages/react-native/Libraries/Components/StatusBar/StatusBar.js
+++ b/packages/react-native/Libraries/Components/StatusBar/StatusBar.js
@@ -20,7 +20,7 @@ import * as React from 'react';
 /**
  * Status bar style
  */
-export type StatusBarStyle = $Keys<{
+export type StatusBarStyle = keyof {
   /**
    * Default status bar style (dark for iOS, light for Android)
    */
@@ -34,12 +34,12 @@ export type StatusBarStyle = $Keys<{
    */
   'dark-content': string,
   ...
-}>;
+};
 
 /**
  * Status bar animation
  */
-export type StatusBarAnimation = $Keys<{
+export type StatusBarAnimation = keyof {
   /**
    * No animation
    */
@@ -53,7 +53,7 @@ export type StatusBarAnimation = $Keys<{
    */
   slide: string,
   ...
-}>;
+};
 
 export type StatusBarPropsAndroid = Readonly<{
   /**
diff --git a/packages/react-native/Libraries/EventEmitter/NativeEventEmitter.js b/packages/react-native/Libraries/EventEmitter/NativeEventEmitter.js
index 9e798c90d95f..86c356f95d3c 100644
--- a/packages/react-native/Libraries/EventEmitter/NativeEventEmitter.js
+++ b/packages/react-native/Libraries/EventEmitter/NativeEventEmitter.js
@@ -83,7 +83,7 @@ export default class NativeEventEmitter<
     }
   }
 
-  addListener<TEvent: $Keys<TEventToArgsMap>>(
+  addListener<TEvent: keyof TEventToArgsMap>(
     eventType: TEvent,
     listener: (...args: TEventToArgsMap[TEvent]) => unknown,
     context?: unknown,
@@ -107,7 +107,7 @@ export default class NativeEventEmitter<
     };
   }
 
-  emit<TEvent: $Keys<TEventToArgsMap>>(
+  emit<TEvent: keyof TEventToArgsMap>(
     eventType: TEvent,
     ...args: TEventToArgsMap[TEvent]
   ): void {
@@ -116,9 +116,7 @@ export default class NativeEventEmitter<
     RCTDeviceEventEmitter.emit(eventType, ...args);
   }
 
-  removeAllListeners<TEvent: $Keys<TEventToArgsMap>>(
-    eventType?: ?TEvent,
-  ): void {
+  removeAllListeners<TEvent: keyof TEventToArgsMap>(eventType?: ?TEvent): void {
     invariant(
       eventType != null,
       '`NativeEventEmitter.removeAllListener()` requires a non-null argument.',
@@ -127,7 +125,7 @@ export default class NativeEventEmitter<
     RCTDeviceEventEmitter.removeAllListeners(eventType);
   }
 
-  listenerCount<TEvent: $Keys<TEventToArgsMap>>(eventType: TEvent): number {
+  listenerCount<TEvent: keyof TEventToArgsMap>(eventType: TEvent): number {
     return RCTDeviceEventEmitter.listenerCount(eventType);
   }
 }
diff --git a/packages/react-native/Libraries/EventEmitter/RCTDeviceEventEmitter.js b/packages/react-native/Libraries/EventEmitter/RCTDeviceEventEmitter.js
index 8ec5f61eb8c3..e8e00e49d087 100644
--- a/packages/react-native/Libraries/EventEmitter/RCTDeviceEventEmitter.js
+++ b/packages/react-native/Libraries/EventEmitter/RCTDeviceEventEmitter.js
@@ -25,7 +25,7 @@ type RCTDeviceEventDefinitions = {[name: string]: Array<any>};
  */
 class RCTDeviceEventEmitterImpl extends EventEmitter<RCTDeviceEventDefinitions> {
   // Add systrace to RCTDeviceEventEmitter.emit method for debugging
-  emit<TEvent: $Keys<RCTDeviceEventDefinitions>>(
+  emit<TEvent: keyof RCTDeviceEventDefinitions>(
     eventType: TEvent,
     ...args: RCTDeviceEventDefinitions[TEvent]
   ): void {
diff --git a/packages/react-native/Libraries/EventEmitter/__mocks__/NativeEventEmitter.js b/packages/react-native/Libraries/EventEmitter/__mocks__/NativeEventEmitter.js
index e978329bd381..bf137ac0ed6e 100644
--- a/packages/react-native/Libraries/EventEmitter/__mocks__/NativeEventEmitter.js
+++ b/packages/react-native/Libraries/EventEmitter/__mocks__/NativeEventEmitter.js
@@ -22,7 +22,7 @@ export default class NativeEventEmitter<
   TEventToArgsMap: Readonly<Record<string, ReadonlyArray<unknown>>>,
 > implements IEventEmitter<TEventToArgsMap>
 {
-  addListener<TEvent: $Keys<TEventToArgsMap>>(
+  addListener<TEvent: keyof TEventToArgsMap>(
     eventType: TEvent,
     listener: (...args: TEventToArgsMap[TEvent]) => unknown,
     context?: unknown,
@@ -30,20 +30,18 @@ export default class NativeEventEmitter<
     return RCTDeviceEventEmitter.addListener(eventType, listener, context);
   }
 
-  emit<TEvent: $Keys<TEventToArgsMap>>(
+  emit<TEvent: keyof TEventToArgsMap>(
     eventType: TEvent,
     ...args: TEventToArgsMap[TEvent]
   ): void {
     RCTDeviceEventEmitter.emit(eventType, ...args);
   }
 
-  removeAllListeners<TEvent: $Keys<TEventToArgsMap>>(
-    eventType?: ?TEvent,
-  ): void {
+  removeAllListeners<TEvent: keyof TEventToArgsMap>(eventType?: ?TEvent): void {
     RCTDeviceEventEmitter.removeAllListeners(eventType);
   }
 
-  listenerCount<TEvent: $Keys<TEventToArgsMap>>(eventType: TEvent): number {
+  listenerCount<TEvent: keyof TEventToArgsMap>(eventType: TEvent): number {
     return RCTDeviceEventEmitter.listenerCount(eventType);
   }
 }
diff --git a/packages/react-native/Libraries/Linking/Linking.js b/packages/react-native/Libraries/Linking/Linking.js
index 1e90ee273908..3af2375e2bbc 100644
--- a/packages/react-native/Libraries/Linking/Linking.js
+++ b/packages/react-native/Libraries/Linking/Linking.js
@@ -32,7 +32,7 @@ class LinkingImpl extends NativeEventEmitter<LinkingEventDefinitions> {
    *
    * See https://reactnative.dev/docs/linking#addeventlistener
    */
-  addEventListener<K: $Keys<LinkingEventDefinitions>>(
+  addEventListener<K: keyof LinkingEventDefinitions>(
     eventType: K,
     listener: (...LinkingEventDefinitions[K]) => unknown,
   ): EventSubscription {
diff --git a/packages/react-native/Libraries/Network/RCTNetworking.android.js b/packages/react-native/Libraries/Network/RCTNetworking.android.js
index 9b155775fc1e..78b68da1ee35 100644
--- a/packages/react-native/Libraries/Network/RCTNetworking.android.js
+++ b/packages/react-native/Libraries/Network/RCTNetworking.android.js
@@ -48,7 +48,7 @@ const emitter = new NativeEventEmitter<$FlowFixMe>(
  * requestId to each network request that can be used to abort that request later on.
  */
 const RCTNetworking = {
-  addListener<K: $Keys<RCTNetworkingEventDefinitions>>(
+  addListener<K: keyof RCTNetworkingEventDefinitions>(
     eventType: K,
     listener: (...RCTNetworkingEventDefinitions[K]) => unknown,
     context?: unknown,
diff --git a/packages/react-native/Libraries/Network/RCTNetworking.ios.js b/packages/react-native/Libraries/Network/RCTNetworking.ios.js
index 454ce4b9176e..ec4720f9f46e 100644
--- a/packages/react-native/Libraries/Network/RCTNetworking.ios.js
+++ b/packages/react-native/Libraries/Network/RCTNetworking.ios.js
@@ -18,7 +18,7 @@ import {type RCTNetworkingEventDefinitions} from './RCTNetworkingEventDefinition
 import {type NativeResponseType} from './XMLHttpRequest';
 
 const RCTNetworking = {
-  addListener<K: $Keys<RCTNetworkingEventDefinitions>>(
+  addListener<K: keyof RCTNetworkingEventDefinitions>(
     eventType: K,
     listener: (...RCTNetworkingEventDefinitions[K]) => unknown,
     context?: unknown,
diff --git a/packages/react-native/Libraries/Network/RCTNetworking.js.flow b/packages/react-native/Libraries/Network/RCTNetworking.js.flow
index 22e3aca18de6..dcafeb05bc44 100644
--- a/packages/react-native/Libraries/Network/RCTNetworking.js.flow
+++ b/packages/react-native/Libraries/Network/RCTNetworking.js.flow
@@ -16,7 +16,7 @@ import type {RCTNetworkingEventDefinitions} from './RCTNetworkingEventDefinition
 import type {NativeResponseType} from './XMLHttpRequest';
 
 declare const RCTNetworking: interface {
-  addListener<K: $Keys<RCTNetworkingEventDefinitions>>(
+  addListener<K: keyof RCTNetworkingEventDefinitions>(
     eventType: K,
     // $FlowFixMe[invalid-computed-prop]
     listener: (...RCTNetworkingEventDefinitions[K]) => unknown,
diff --git a/packages/react-native/Libraries/PushNotificationIOS/PushNotificationIOS.js b/packages/react-native/Libraries/PushNotificationIOS/PushNotificationIOS.js
index 26e1dacfb47c..ddc0389e0b7d 100644
--- a/packages/react-native/Libraries/PushNotificationIOS/PushNotificationIOS.js
+++ b/packages/react-native/Libraries/PushNotificationIOS/PushNotificationIOS.js
@@ -89,7 +89,7 @@ export type FetchResult = {
 /**
  * An event emitted by PushNotificationIOS.
  */
-export type PushNotificationEventName = $Keys<{
+export type PushNotificationEventName = keyof {
   /**
    * Fired when a remote notification is received. The handler will be invoked
    * with an instance of `PushNotificationIOS`. This will handle notifications
@@ -116,7 +116,7 @@ export type PushNotificationEventName = $Keys<{
    */
   registrationError: string,
   ...
-}>;
+};
 
 export interface PushNotification {
   /**
diff --git a/packages/react-native/Libraries/ReactNative/RendererImplementation.js b/packages/react-native/Libraries/ReactNative/RendererImplementation.js
index f9e439a84cd9..5874de821cf1 100644
--- a/packages/react-native/Libraries/ReactNative/RendererImplementation.js
+++ b/packages/react-native/Libraries/ReactNative/RendererImplementation.js
@@ -37,11 +37,11 @@ function getPaperRenderer(): ReactNativeType {
   return cachedPaperRenderer;
 }
 
-const getMethod: (<MethodName: $Keys<ReactFabricType>>(
+const getMethod: (<MethodName: keyof ReactFabricType>(
   () => ReactFabricType,
   MethodName,
 ) => ReactFabricType[MethodName]) &
-  (<MethodName: $Keys<ReactNativeType>>(
+  (<MethodName: keyof ReactNativeType>(
     () => ReactNativeType,
     MethodName,
   ) => ReactNativeType[MethodName]) = (getRenderer, methodName) => {
@@ -59,13 +59,13 @@ const getMethod: (<MethodName: $Keys<ReactFabricType>>(
   };
 };
 
-function getFabricMethod<MethodName: $Keys<ReactFabricType>>(
+function getFabricMethod<MethodName: keyof ReactFabricType>(
   methodName: MethodName,
 ): ReactFabricType[MethodName] {
   return getMethod(getFabricRenderer, methodName);
 }
 
-function getPaperMethod<MethodName: $Keys<ReactNativeType>>(
+function getPaperMethod<MethodName: keyof ReactNativeType>(
   methodName: MethodName,
 ): ReactNativeType[MethodName] {
   return getMethod(getPaperRenderer, methodName);
diff --git a/packages/react-native/Libraries/StyleSheet/StyleSheet.js b/packages/react-native/Libraries/StyleSheet/StyleSheet.js
index 3bbfa9031f30..23dedbe8552f 100644
--- a/packages/react-native/Libraries/StyleSheet/StyleSheet.js
+++ b/packages/react-native/Libraries/StyleSheet/StyleSheet.js
@@ -118,7 +118,7 @@ export type DangerouslyImpreciseStyleProp =
  * This will correctly give you the type 'absolute' | 'relative'
  */
 export type TypeForStyleKey<
-  +key: $Keys<____DangerouslyImpreciseStyle_Internal>,
+  +key: keyof ____DangerouslyImpreciseStyle_Internal,
 > = ____DangerouslyImpreciseStyle_Internal[key];
 
 /**
diff --git a/packages/react-native/Libraries/StyleSheet/StyleSheet.js.flow b/packages/react-native/Libraries/StyleSheet/StyleSheet.js.flow
index 73ebfd9bfb0a..f72489b8815e 100644
--- a/packages/react-native/Libraries/StyleSheet/StyleSheet.js.flow
+++ b/packages/react-native/Libraries/StyleSheet/StyleSheet.js.flow
@@ -119,7 +119,7 @@ export type DangerouslyImpreciseStyleProp =
  * This will correctly give you the type 'absolute' | 'relative'
  */
 export type TypeForStyleKey<
-  +key: $Keys<____DangerouslyImpreciseStyle_Internal>,
+  +key: keyof ____DangerouslyImpreciseStyle_Internal,
 > = ____DangerouslyImpreciseStyle_Internal[key];
 
 /**
diff --git a/packages/react-native/Libraries/StyleSheet/private/_TransformStyle.js b/packages/react-native/Libraries/StyleSheet/private/_TransformStyle.js
index ec6b7586d01e..b152e41164ba 100644
--- a/packages/react-native/Libraries/StyleSheet/private/_TransformStyle.js
+++ b/packages/react-native/Libraries/StyleSheet/private/_TransformStyle.js
@@ -13,10 +13,10 @@ import type AnimatedNode from '../../Animated/nodes/AnimatedNode';
 // Helper types to enforce that a single key is used in a transform object
 // after generating a TypeScript definition file from the Flow types.
 // $FlowExpectedError[unclear-type]
-type KeysOfUnion<T> = T extends any ? $Keys<T> : empty;
+type KeysOfUnion<T> = T extends any ? keyof T : empty;
 // $FlowExpectedError[unclear-type]
 type ValueOfUnion<T, K> = T extends any
-  ? K extends $Keys<T>
+  ? K extends keyof T
     ? T[K]
     : empty
   : empty;
diff --git a/packages/react-native/Libraries/Types/ReactDevToolsTypes.js b/packages/react-native/Libraries/Types/ReactDevToolsTypes.js
index 74baa27ff1de..767f5461f290 100644
--- a/packages/react-native/Libraries/Types/ReactDevToolsTypes.js
+++ b/packages/react-native/Libraries/Types/ReactDevToolsTypes.js
@@ -34,12 +34,12 @@ export type ReactDevToolsAgentEvents = {
 export type ReactDevToolsAgent = {
   selectNode(node: unknown): void,
   stopInspectingNative(value: boolean): void,
-  addListener<Event: $Keys<ReactDevToolsAgentEvents>>(
+  addListener<Event: keyof ReactDevToolsAgentEvents>(
     event: Event,
     listener: (...ReactDevToolsAgentEvents[Event]) => void,
   ): void,
   removeListener(
-    event: $Keys<ReactDevToolsAgentEvents>,
+    event: keyof ReactDevToolsAgentEvents,
     listener: () => void,
   ): void,
 };
diff --git a/packages/react-native/Libraries/Utilities/codegenNativeCommands.js b/packages/react-native/Libraries/Utilities/codegenNativeCommands.js
index c4ce2aa9d4d5..f3a829738373 100644
--- a/packages/react-native/Libraries/Utilities/codegenNativeCommands.js
+++ b/packages/react-native/Libraries/Utilities/codegenNativeCommands.js
@@ -15,9 +15,9 @@ type NativeCommandsOptions<T = string> = Readonly<{
 }>;
 
 function codegenNativeCommands<T: interface {}>(
-  options: NativeCommandsOptions<$Keys<T>>,
+  options: NativeCommandsOptions<keyof T>,
 ): T {
-  const commandObj: {[$Keys<T>]: (...ReadonlyArray<unknown>) => void} = {};
+  const commandObj: {[keyof T]: (...ReadonlyArray<unknown>) => void} = {};
 
   options.supportedCommands.forEach(command => {
     // $FlowFixMe[missing-local-annot]
diff --git a/packages/react-native/Libraries/vendor/emitter/EventEmitter.js b/packages/react-native/Libraries/vendor/emitter/EventEmitter.js
index 05d668dee422..7fc5515aaaf6 100644
--- a/packages/react-native/Libraries/vendor/emitter/EventEmitter.js
+++ b/packages/react-native/Libraries/vendor/emitter/EventEmitter.js
@@ -18,20 +18,20 @@ export interface EventSubscription {
 export interface IEventEmitter<
   TEventToArgsMap: Readonly<Record<string, ReadonlyArray<UnsafeEventObject>>>,
 > {
-  addListener<TEvent: $Keys<TEventToArgsMap>>(
+  addListener<TEvent: keyof TEventToArgsMap>(
     eventType: TEvent,
     listener: (...args: TEventToArgsMap[TEvent]) => unknown,
     context?: unknown,
   ): EventSubscription;
 
-  emit<TEvent: $Keys<TEventToArgsMap>>(
+  emit<TEvent: keyof TEventToArgsMap>(
     eventType: TEvent,
     ...args: TEventToArgsMap[TEvent]
   ): void;
 
-  removeAllListeners<TEvent: $Keys<TEventToArgsMap>>(eventType?: ?TEvent): void;
+  removeAllListeners<TEvent: keyof TEventToArgsMap>(eventType?: ?TEvent): void;
 
-  listenerCount<TEvent: $Keys<TEventToArgsMap>>(eventType: TEvent): number;
+  listenerCount<TEvent: keyof TEventToArgsMap>(eventType: TEvent): number;
 }
 
 interface Registration<TArgs> {
@@ -83,7 +83,7 @@ export default class EventEmitter<
    * Registers a listener that is called when the supplied event is emitted.
    * Returns a subscription that has a `remove` method to undo registration.
    */
-  addListener<TEvent: $Keys<TEventToArgsMap>>(
+  addListener<TEvent: keyof TEventToArgsMap>(
     eventType: TEvent,
     listener: (...args: TEventToArgsMap[TEvent]) => unknown,
     context: unknown,
@@ -95,7 +95,7 @@ export default class EventEmitter<
     }
     const registrations = allocate<
       TEventToArgsMap,
-      $Keys<TEventToArgsMap>,
+      keyof TEventToArgsMap,
       TEventToArgsMap[TEvent],
     >(this.#registry, eventType);
     const registration: Registration<TEventToArgsMap[TEvent]> = {
@@ -116,7 +116,7 @@ export default class EventEmitter<
    * If a listener modifies the listeners registered for the same event, those
    * changes will not be reflected in the current invocation of `emit`.
    */
-  emit<TEvent: $Keys<TEventToArgsMap>>(
+  emit<TEvent: keyof TEventToArgsMap>(
     eventType: TEvent,
     ...args: TEventToArgsMap[TEvent]
   ): void {
@@ -135,9 +135,7 @@ export default class EventEmitter<
   /**
    * Removes all registered listeners.
    */
-  removeAllListeners<TEvent: $Keys<TEventToArgsMap>>(
-    eventType?: ?TEvent,
-  ): void {
+  removeAllListeners<TEvent: keyof TEventToArgsMap>(eventType?: ?TEvent): void {
     if (eventType == null) {
       // $FlowFixMe[incompatible-type]
       this.#registry = {};
@@ -149,7 +147,7 @@ export default class EventEmitter<
   /**
    * Returns the number of registered listeners for the supplied event.
    */
-  listenerCount<TEvent: $Keys<TEventToArgsMap>>(eventType: TEvent): number {
+  listenerCount<TEvent: keyof TEventToArgsMap>(eventType: TEvent): number {
     const registrations: ?Set<Registration<TEventToArgsMap[TEvent]>> =
       this.#registry[eventType];
     return registrations == null ? 0 : registrations.size;
@@ -158,7 +156,7 @@ export default class EventEmitter<
 
 function allocate<
   TEventToArgsMap: Readonly<Record<string, ReadonlyArray<UnsafeEventObject>>>,
-  TEvent: $Keys<TEventToArgsMap>,
+  TEvent: keyof TEventToArgsMap,
   TEventArgs: TEventToArgsMap[TEvent],
 >(
   registry: Registry<TEventToArgsMap>,
diff --git a/packages/react-native/src/private/__tests__/MemoryBaseline-itest.js b/packages/react-native/src/private/__tests__/MemoryBaseline-itest.js
index dab58d04617a..a85f804aa39d 100644
--- a/packages/react-native/src/private/__tests__/MemoryBaseline-itest.js
+++ b/packages/react-native/src/private/__tests__/MemoryBaseline-itest.js
@@ -38,7 +38,7 @@ const MEMORY_LIMITS_KB = {
   },
 };
 
-function limitFor(scenario: $Keys<typeof MEMORY_LIMITS_KB>): number {
+function limitFor(scenario: keyof typeof MEMORY_LIMITS_KB): number {
   return MEMORY_LIMITS_KB[scenario][__DEV__ ? 'dev' : 'opt'];
 }
 
diff --git a/packages/react-native/src/private/__tests__/utilities/accessibilityPropsSuite.js b/packages/react-native/src/private/__tests__/utilities/accessibilityPropsSuite.js
index ec3877292ec2..62933747b3d5 100644
--- a/packages/react-native/src/private/__tests__/utilities/accessibilityPropsSuite.js
+++ b/packages/react-native/src/private/__tests__/utilities/accessibilityPropsSuite.js
@@ -118,7 +118,7 @@ let root: Root;
 
 function getAccessibilityProp(
   content: React.MixedElement,
-  name: $Keys<AccessibilityProps>,
+  name: keyof AccessibilityProps,
 ) {
   Fantom.runTask(() => {
     root.render(content);
@@ -128,7 +128,7 @@ function getAccessibilityProp(
 
 function getAccessibilityProps(
   content: React.MixedElement,
-  names: ReadonlyArray<$Keys<AccessibilityProps>>,
+  names: ReadonlyArray<keyof AccessibilityProps>,
 ) {
   Fantom.runTask(() => {
     root.render(content);
diff --git a/packages/react-native/src/private/featureflags/ReactNativeFeatureFlagsBase.js b/packages/react-native/src/private/featureflags/ReactNativeFeatureFlagsBase.js
index 0d6c2cd17023..dcc7e6cc5a86 100644
--- a/packages/react-native/src/private/featureflags/ReactNativeFeatureFlagsBase.js
+++ b/packages/react-native/src/private/featureflags/ReactNativeFeatureFlagsBase.js
@@ -52,7 +52,7 @@ function createGetter<T: boolean | number | string>(
 }
 
 export function createJavaScriptFlagGetter<
-  K: $Keys<ReactNativeFeatureFlagsJsOnly>,
+  K: keyof ReactNativeFeatureFlagsJsOnly,
 >(
   configName: K,
   defaultValue: ReturnType<ReactNativeFeatureFlagsJsOnly[K]>,
@@ -69,7 +69,7 @@ export function createJavaScriptFlagGetter<
 
 type NativeFeatureFlags = NonNullable<typeof NativeReactNativeFeatureFlags>;
 
-export function createNativeFlagGetter<K: $Keys<NativeFeatureFlags>>(
+export function createNativeFlagGetter<K: keyof NativeFeatureFlags>(
   configName: K,
   defaultValue: ReturnType<NonNullable<NativeFeatureFlags[K]>>,
   skipUnavailableNativeModuleError: boolean = false,
diff --git a/packages/rn-tester/js/utils/RNTesterNavigationReducer.js b/packages/rn-tester/js/utils/RNTesterNavigationReducer.js
index a952455b82fc..df7080288e8d 100644
--- a/packages/rn-tester/js/utils/RNTesterNavigationReducer.js
+++ b/packages/rn-tester/js/utils/RNTesterNavigationReducer.js
@@ -55,7 +55,7 @@ const getUpdatedRecentlyUsed = ({
 
 export const RNTesterNavigationReducer = (
   state: RNTesterNavigationState,
-  action: {type: $Keys<typeof RNTesterNavigationActionsType>, data?: any},
+  action: {type: keyof typeof RNTesterNavigationActionsType, data?: any},
 ): RNTesterNavigationState => {
   const {
     data: {
diff --git a/packages/virtualized-lists/Lists/StateSafePureComponent.js b/packages/virtualized-lists/Lists/StateSafePureComponent.js
index 3e04fd9c7354..65eee4b243d0 100644
--- a/packages/virtualized-lists/Lists/StateSafePureComponent.js
+++ b/packages/virtualized-lists/Lists/StateSafePureComponent.js
@@ -32,7 +32,7 @@ export default class StateSafePureComponent<
   }
 
   // $FlowFixMe[incompatible-type]
-  setState<K: $Keys<State>>(
+  setState<K: keyof State>(
     partialState: ?(Pick<State, K> | ((State, Props) => ?Pick<State, K>)),
     callback?: () => unknown,
   ): void {
diff --git a/scripts/build/config.js b/scripts/build/config.js
index 99b827e95d90..a27b6363ada7 100644
--- a/scripts/build/config.js
+++ b/scripts/build/config.js
@@ -70,7 +70,7 @@ const defaultBuildOptions = {
 };
 
 function getBuildOptions(
-  packageName: $Keys<BuildConfig['packages']>,
+  packageName: keyof BuildConfig['packages'],
 ): Required<BuildOptions> {
   return {
     ...defaultBuildOptions,
@@ -79,7 +79,7 @@ function getBuildOptions(
 }
 
 function getBabelConfig(
-  packageName: $Keys<BuildConfig['packages']>,
+  packageName: keyof BuildConfig['packages'],
 ): BabelCoreOptions {
   const {target} = getBuildOptions(packageName);
 
@@ -90,7 +90,7 @@ function getBabelConfig(
 }
 
 function getTypeScriptCompilerOptions(
-  packageName: $Keys<BuildConfig['packages']>,
+  packageName: keyof BuildConfig['packages'],
 ): Object {
   const {target} = getBuildOptions(packageName);