diff --git a/packages/bigframes/noxfile.py b/packages/bigframes/noxfile.py
index 537d417e9145..111efbcba368 100644
--- a/packages/bigframes/noxfile.py
+++ b/packages/bigframes/noxfile.py
@@ -945,6 +945,7 @@ def core_deps_from_source(session, protobuf_implementation):
     rather than pulling the dependencies from PyPI.
     """
 
+    # Trigger CI run for core_deps_from_source
     # Install all dependencies
     session.install("-e", ".")
 
diff --git a/packages/db-dtypes/noxfile.py b/packages/db-dtypes/noxfile.py
index f8c72afd2814..381ab96b5f37 100644
--- a/packages/db-dtypes/noxfile.py
+++ b/packages/db-dtypes/noxfile.py
@@ -485,13 +485,49 @@ def docfx(session):
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
-def core_deps_from_source(session):
+@nox.parametrize(
+    "protobuf_implementation",
+    ["python", "upb"],
+)
+def core_deps_from_source(session, protobuf_implementation):
     """Run all tests with core dependencies installed from source
     rather than pulling the dependencies from PyPI.
     """
-    # TODO(https://github.com/googleapis/google-cloud-python/issues/16014):
-    # Add core deps from source tests
-    session.skip("Core deps from source tests are not yet supported")
+    constraints_path = str(
+        CURRENT_DIRECTORY / "testing" / f"constraints-{session.python}.txt"
+    )
+    install_unittest_dependencies(session, "-c", constraints_path)
+
+    core_dependencies_from_source = [
+        "googleapis-common-protos @ git+https://github.com/googleapis/google-cloud-python#egg=googleapis-common-protos&subdirectory=packages/googleapis-common-protos",
+        "google-api-core @ git+https://github.com/googleapis/google-cloud-python#egg=google-api-core&subdirectory=packages/google-api-core",
+        "google-auth @ git+https://github.com/googleapis/google-cloud-python#egg=google-auth&subdirectory=packages/google-auth",
+        "grpc-google-iam-v1 @ git+https://github.com/googleapis/google-cloud-python#egg=grpc-google-iam-v1&subdirectory=packages/grpc-google-iam-v1",
+        "proto-plus @ git+https://github.com/googleapis/google-cloud-python#egg=proto-plus&subdirectory=packages/proto-plus",
+    ]
+
+    for dep in core_dependencies_from_source:
+        session.install(dep, "--no-deps", "--ignore-installed")
+        print(f"Installed {dep}")
+
+    tests_path = os.path.join("tests", "unit")
+    session.run(
+        "py.test",
+        "--quiet",
+        "-W default::FutureWarning",
+        f"--junitxml=unit_{session.python}_sponge_log.xml",
+        "--cov=db_dtypes",
+        "--cov=tests/unit",
+        "--cov-append",
+        "--cov-config=.coveragerc",
+        "--cov-report=",
+        "--cov-fail-under=0",
+        tests_path,
+        *session.posargs,
+        env={
+            "PROTOCOL_BUFFERS_PYTHON_IMPLEMENTATION": protobuf_implementation,
+        },
+    )
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
diff --git a/packages/google-cloud-documentai-toolbox/noxfile.py b/packages/google-cloud-documentai-toolbox/noxfile.py
index 0f0a1a17db2a..18ecc88ef61b 100644
--- a/packages/google-cloud-documentai-toolbox/noxfile.py
+++ b/packages/google-cloud-documentai-toolbox/noxfile.py
@@ -509,7 +509,43 @@ def mypy(session):
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
-def core_deps_from_source(session):
-    # TODO(https://github.com/googleapis/google-cloud-python/issues/16014):
-    # Enable this test once this bug is fixed.
-    session.skip("Temporarily skip core_deps_from_source. See issue 16014")
+@nox.parametrize(
+    "protobuf_implementation",
+    ["python", "upb"],
+)
+def core_deps_from_source(session, protobuf_implementation):
+    """Run all tests with core dependencies installed from source"""
+    constraints_path = str(
+        CURRENT_DIRECTORY / "testing" / f"constraints-{session.python}.txt"
+    )
+    install_unittest_dependencies(session, "-c", constraints_path)
+
+    core_dependencies_from_source = [
+        "googleapis-common-protos @ git+https://github.com/googleapis/google-cloud-python#egg=googleapis-common-protos&subdirectory=packages/googleapis-common-protos",
+        "google-api-core @ git+https://github.com/googleapis/google-cloud-python#egg=google-api-core&subdirectory=packages/google-api-core",
+        "google-auth @ git+https://github.com/googleapis/google-cloud-python#egg=google-auth&subdirectory=packages/google-auth",
+        "grpc-google-iam-v1 @ git+https://github.com/googleapis/google-cloud-python#egg=grpc-google-iam-v1&subdirectory=packages/grpc-google-iam-v1",
+        "proto-plus @ git+https://github.com/googleapis/google-cloud-python#egg=proto-plus&subdirectory=packages/proto-plus",
+    ]
+
+    for dep in core_dependencies_from_source:
+        session.install(dep, "--no-deps", "--ignore-installed")
+        print(f"Installed {dep}")
+
+    tests_path = os.path.join("tests", "unit")
+    session.run(
+        "py.test",
+        "--quiet",
+        f"--junitxml=unit_{session.python}_sponge_log.xml",
+        "--cov=google",
+        "--cov=tests/unit",
+        "--cov-append",
+        "--cov-config=.coveragerc",
+        "--cov-report=",
+        "--cov-fail-under=0",
+        tests_path,
+        *session.posargs,
+        env={
+            "PROTOCOL_BUFFERS_PYTHON_IMPLEMENTATION": protobuf_implementation,
+        },
+    )
diff --git a/packages/google-cloud-ndb/noxfile.py b/packages/google-cloud-ndb/noxfile.py
index 20ffac1aa36d..e95958c0226d 100644
--- a/packages/google-cloud-ndb/noxfile.py
+++ b/packages/google-cloud-ndb/noxfile.py
@@ -444,10 +444,46 @@ def system_default(session):
 
 
 @nox.session(python=DEFAULT_INTERPRETER)
-def core_deps_from_source(session):
-    # TODO(https://github.com/googleapis/google-cloud-python/issues/16014):
-    # Enable this test once this bug is fixed.
-    session.skip("Temporarily skip core_deps_from_source. See issue 16014")
+@nox.parametrize(
+    "protobuf_implementation",
+    ["python", "upb"],
+)
+def core_deps_from_source(session, protobuf_implementation):
+    """Run all tests with core dependencies installed from source"""
+    constraints_path = str(
+        CURRENT_DIRECTORY / "testing" / f"constraints-{session.python}.txt"
+    )
+    install_unittest_dependencies(session, "-c", constraints_path)
+
+    core_dependencies_from_source = [
+        "googleapis-common-protos @ git+https://github.com/googleapis/google-cloud-python#egg=googleapis-common-protos&subdirectory=packages/googleapis-common-protos",
+        "google-api-core @ git+https://github.com/googleapis/google-cloud-python#egg=google-api-core&subdirectory=packages/google-api-core",
+        "google-auth @ git+https://github.com/googleapis/google-cloud-python#egg=google-auth&subdirectory=packages/google-auth",
+        "grpc-google-iam-v1 @ git+https://github.com/googleapis/google-cloud-python#egg=grpc-google-iam-v1&subdirectory=packages/grpc-google-iam-v1",
+        "proto-plus @ git+https://github.com/googleapis/google-cloud-python#egg=proto-plus&subdirectory=packages/proto-plus",
+    ]
+
+    for dep in core_dependencies_from_source:
+        session.install(dep, "--no-deps", "--ignore-installed")
+        print(f"Installed {dep}")
+
+    tests_path = os.path.join("tests", "unit")
+    session.run(
+        "py.test",
+        "--quiet",
+        f"--junitxml=unit_{session.python}_sponge_log.xml",
+        "--cov=google",
+        "--cov=tests/unit",
+        "--cov-append",
+        "--cov-config=.coveragerc",
+        "--cov-report=",
+        "--cov-fail-under=0",
+        tests_path,
+        *session.posargs,
+        env={
+            "PROTOCOL_BUFFERS_PYTHON_IMPLEMENTATION": protobuf_implementation,
+        },
+    )
 
 
 @nox.session(python=DEFAULT_INTERPRETER)
diff --git a/packages/pandas-gbq/noxfile.py b/packages/pandas-gbq/noxfile.py
index 19f824f12a0e..0b6b63c1a5d6 100644
--- a/packages/pandas-gbq/noxfile.py
+++ b/packages/pandas-gbq/noxfile.py
@@ -533,10 +533,47 @@ def mypy(session):
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
-def core_deps_from_source(session):
+@nox.parametrize(
+    "protobuf_implementation",
+    ["python", "upb"],
+)
+@_calculate_duration
+def core_deps_from_source(session, protobuf_implementation):
     """Run all tests with core dependencies installed from source
     rather than pulling the dependencies from PyPI.
     """
-    # TODO(https://github.com/googleapis/google-cloud-python/issues/16014):
-    # Add core deps from source tests
-    session.skip("Core deps from source tests are not yet supported")
+    constraints_path = str(
+        CURRENT_DIRECTORY / "testing" / f"constraints-{session.python}.txt"
+    )
+    install_unittest_dependencies(session, "-c", constraints_path)
+
+    core_dependencies_from_source = [
+        "googleapis-common-protos @ git+https://github.com/googleapis/google-cloud-python#egg=googleapis-common-protos&subdirectory=packages/googleapis-common-protos",
+        "google-api-core @ git+https://github.com/googleapis/google-cloud-python#egg=google-api-core&subdirectory=packages/google-api-core",
+        "google-auth @ git+https://github.com/googleapis/google-cloud-python#egg=google-auth&subdirectory=packages/google-auth",
+        "grpc-google-iam-v1 @ git+https://github.com/googleapis/google-cloud-python#egg=grpc-google-iam-v1&subdirectory=packages/grpc-google-iam-v1",
+        "proto-plus @ git+https://github.com/googleapis/google-cloud-python#egg=proto-plus&subdirectory=packages/proto-plus",
+    ]
+
+    for dep in core_dependencies_from_source:
+        session.install(dep, "--no-deps", "--ignore-installed")
+        print(f"Installed {dep}")
+
+    tests_path = os.path.join("tests", "unit")
+    session.run(
+        "py.test",
+        "--quiet",
+        "-W default::PendingDeprecationWarning",
+        f"--junitxml=unit_{session.python}_sponge_log.xml",
+        "--cov=pandas_gbq",
+        "--cov=tests/unit",
+        "--cov-append",
+        "--cov-config=.coveragerc",
+        "--cov-report=",
+        "--cov-fail-under=0",
+        tests_path,
+        *session.posargs,
+        env={
+            "PROTOCOL_BUFFERS_PYTHON_IMPLEMENTATION": protobuf_implementation,
+        },
+    )
diff --git a/packages/sqlalchemy-bigquery/noxfile.py b/packages/sqlalchemy-bigquery/noxfile.py
index 7a8ba6cdfc2a..496b41747beb 100644
--- a/packages/sqlalchemy-bigquery/noxfile.py
+++ b/packages/sqlalchemy-bigquery/noxfile.py
@@ -697,10 +697,53 @@ def mypy(session):
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
-def core_deps_from_source(session):
+@nox.parametrize(
+    "protobuf_implementation",
+    ["python", "upb"],
+)
+@_calculate_duration
+def core_deps_from_source(session, protobuf_implementation):
     """Run all tests with core dependencies installed from source
     rather than pulling the dependencies from PyPI.
     """
-    # TODO(https://github.com/googleapis/google-cloud-python/issues/16014):
-    # Add core deps from source tests
-    session.skip("Core deps from source tests are not yet supported")
+    constraints_path = str(
+        CURRENT_DIRECTORY / "testing" / f"constraints-{session.python}.txt"
+    )
+    install_unittest_dependencies(session, "-c", constraints_path)
+
+    # Mimic unit session install target
+    if session.python in ["3.11", "3.12", "3.13", "3.14"]:
+        install_target = ".[geography,alembic,tests,bqstorage]"
+    else:
+        install_target = ".[all]"
+    session.install("-e", install_target, "-c", constraints_path)
+
+    core_dependencies_from_source = [
+        "googleapis-common-protos @ git+https://github.com/googleapis/google-cloud-python#egg=googleapis-common-protos&subdirectory=packages/googleapis-common-protos",
+        "google-api-core @ git+https://github.com/googleapis/google-cloud-python#egg=google-api-core&subdirectory=packages/google-api-core",
+        "google-auth @ git+https://github.com/googleapis/google-cloud-python#egg=google-auth&subdirectory=packages/google-auth",
+        "grpc-google-iam-v1 @ git+https://github.com/googleapis/google-cloud-python#egg=grpc-google-iam-v1&subdirectory=packages/grpc-google-iam-v1",
+        "proto-plus @ git+https://github.com/googleapis/google-cloud-python#egg=proto-plus&subdirectory=packages/proto-plus",
+    ]
+
+    for dep in core_dependencies_from_source:
+        session.install(dep, "--no-deps", "--ignore-installed")
+        print(f"Installed {dep}")
+
+    tests_path = os.path.join("tests", "unit")
+    session.run(
+        "py.test",
+        "--quiet",
+        f"--junitxml=unit_{session.python}_sponge_log.xml",
+        "--cov=sqlalchemy_bigquery",
+        "--cov=tests/unit",
+        "--cov-append",
+        "--cov-config=.coveragerc",
+        "--cov-report=",
+        "--cov-fail-under=0",
+        tests_path,
+        *session.posargs,
+        env={
+            "PROTOCOL_BUFFERS_PYTHON_IMPLEMENTATION": protobuf_implementation,
+        },
+    )
diff --git a/packages/sqlalchemy-spanner/noxfile.py b/packages/sqlalchemy-spanner/noxfile.py
index f0e115ef3ed5..5a640f4d617c 100644
--- a/packages/sqlalchemy-spanner/noxfile.py
+++ b/packages/sqlalchemy-spanner/noxfile.py
@@ -411,9 +411,42 @@ def mypy(session):
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
-def core_deps_from_source(session):
+@nox.parametrize(
+    "protobuf_implementation",
+    ["python", "upb"],
+)
+def core_deps_from_source(session, protobuf_implementation):
     """Run all tests with core dependencies installed from source"""
-    session.skip("Core deps from source tests are not yet supported")
+    session.install("setuptools")
+    session.install("pytest")
+    session.install("mock")
+    session.install(".")
+    session.install("opentelemetry-api")
+    session.install("opentelemetry-sdk")
+    session.install("opentelemetry-instrumentation")
+
+    core_dependencies_from_source = [
+        "googleapis-common-protos @ git+https://github.com/googleapis/google-cloud-python#egg=googleapis-common-protos&subdirectory=packages/googleapis-common-protos",
+        "google-api-core @ git+https://github.com/googleapis/google-cloud-python#egg=google-api-core&subdirectory=packages/google-api-core",
+        "google-auth @ git+https://github.com/googleapis/google-cloud-python#egg=google-auth&subdirectory=packages/google-auth",
+        "grpc-google-iam-v1 @ git+https://github.com/googleapis/google-cloud-python#egg=grpc-google-iam-v1&subdirectory=packages/grpc-google-iam-v1",
+        "proto-plus @ git+https://github.com/googleapis/google-cloud-python#egg=proto-plus&subdirectory=packages/proto-plus",
+    ]
+
+    for dep in core_dependencies_from_source:
+        session.install(dep, "--no-deps", "--ignore-installed")
+        print(f"Installed {dep}")
+
+    tests_path = os.path.join("tests", "unit")
+    session.run(
+        "py.test",
+        "--quiet",
+        tests_path,
+        *session.posargs,
+        env={
+            "PROTOCOL_BUFFERS_PYTHON_IMPLEMENTATION": protobuf_implementation,
+        },
+    )
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)